Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis
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چکیده
منابع مشابه
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★
Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to central metabolic sensing, partially by acting in leptin receptor (LepRb)-expressing neurons. Although Irs4 is largely restricted to the hypothalamus, its contribution to metaboli...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2014
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2013.10.004